Bacterial & Viral Infections: Silver Iontophoresis

Topic: Bacterial Infection, Viral Infection, Superbug, Antibiotic Resistant, Silver Iontophoresis Treatment

Bacterial Infection, Viral Infection, Superbug, Antibiotic Resistant, Silver Iontophoresis Treatment

How does the treatment work?

Silver iontophoresis uses an electric field, just as is generated between the ends of a battery, to generate and move atoms of silver having a positive electrical charge (Ag+), called ‘cations’. The ‘cations’ can be delivered through the skin deeper into the body for the treatment of an internal infection; they can also be delivered across the skin surface for surface infections.

Silver iontophoresis is achieved with very low intensity, sub-sensory (no pain) electric currents. This is targeted treatment, with no drug side effects. 

The treatment system is non-invasive, and essentially similar to the patented antimicrobial system developed by the electromedical pioneer, Robert O Becker and his team.

What infections can be treated?

Silver iontophoresis can be targeted at virtually any localized bacterial or viral infection including:

  • Ear, nose and throat (ENT) infections including sinus infections
  • Gum infections (gingivitis)
  • Chest (upper and lower respiratory tract) infections: Bronchitis, Pneumonia
  • Stomach infections such as Helicobacter pylori
  • Liver infections (viral hepatitis)
  • Herpes viruses infections
  • Pancreatic infections
  • Spleen infections
  • Reproductive organ infections (male & female) including ovarian, uterine and cervical infections: HPV
  • Bladder and Kidney infections (upper and lower UTI)
  • Bone, joint and muscle infections (Osteomyelitis, Septic Arthritis, Pyomyositis).
  • Antibiotic resistant superbugs

How is it applied?

The portable iontophoresis equipment is applied during a clinic session. The equipment includes silver-nylon cloth electrodes attached to the body, and a portable, palm-size electro-stimulator. The equipment is taken home by the patient for continuous use over a number of days. Alternatively, a series of treatment sessions in the clinic can be applied.

Results

To illustrate the effectiveness of this treatment system, some of the results of our silver iontophoresis treatments for various infections are recorded here.

The medical science behind this treatment system is far from new. There are extensive medical-scientific journal articles on the effectiveness and method of action of electrically produced silver ions as powerful antibacterial and antiviral agents, including by the USA military.


Academic References

The following citations are supporting international medical-scientific journal published articles:

Silver Iontophoresis

Becker RO, Spadaro JA. Treatment of orthopaedic infections with electrically generated silver ions. A preliminary report. J Bone Joint Surg Am. 1978 Oct;60(7):871-81.

Nand S, Sengar GK, Nand S, Jain VK, Gupta TD. Dual use of silver for management of chronic bone infections and infected non-unions. J Indian Med Assoc. 1996 Mar;94(3):91-5.

Webster DA, Spadaro JA, Becker RO, Kramer S. Silver anode treatment of chronic osteomyelitis. Clin Orthop Relat Res. 1981 Nov-Dec;(161):105-14.

Becker RO. Processes and products involving cell modificationUS 4528265 A. Jul 9, 1985

Becker RO, Flick AB, Becker AJ. Iontopheretic system for stimulation of tissue healing and regenerationUS 5814094 A. Sep 29, 1998.

Chu CS, McManus AT, Pruitt BA Jr, Mason AD Jr. Therapeutic effects of silver nylon dressings with weak direct current on Pseudomonas aeruginosa-infected burn wounds. J Trauma. 1988 Oct;28(10):1488-92.

Satyanand, Saxena AK, Agarwal A. Silver iontophoresis in chronic osteomyelitis. J Indian Med Assoc. 1986 May;84(5):134-6.

Uezono H. Effect of weak direct current with silver electrodes on bacterial growth. Nihon Seikeigeka Gakkai Zasshi. 1990 Sep;64(9):860-7. Department of Orthopaedic Surgery, Faculty of Medicine, Kagoshima University, Japan.

Raad I, Hachem R, Zermeno A, Stephens LC, Bodey GP. Silver iontophoretic catheter: a prototype of a long-term antiinfective vascular access device. J Infect Dis. 1996 Feb;173(2):495-8.

Low Voltage Iontophoresis

Chizmadzhev YA, Indenbom AV, Kuzmin PI, Galichenko SV, Weaver JC, Potts RO. Electrical properties of skin at moderate voltages: contribution of appendageal macropores. Biophys J. 1998 Feb;74(2 Pt 1):843-56.

Kasting GB, Bowman LA. DC electrical properties of frozen, excised human skin. Pharm Res. 1990 Feb;7(2):134-43.

Silver-Nylon Cloth is an Effective Antibacterial agent

Deitch EA, Marino AA, Malakanok V, Albright JA. Silver nylon cloth: in vitro and in vivo evaluation of antimicrobial activity. J Trauma. 1987 Mar;27(3):301-4.

Deitch EA, Marino AA, Gillespie TE, Albright JA. Silver-nylon: a new antimicrobial agent. Antimicrob Agents Chemother. 1983 Mar;23(3):356-9.

P C MacKeen, S Person, S C Warner, W Snipes, S E Stevens, Jr. Silver-coated nylon fiber as an antibacterial agent. Antimicrob Agents Chemother. Jan 1987; 31(1): 93–99.

Barillo DJ, Pozza M, Margaret-Brandt M. A literature review of the military uses of silver-nylon dressings with emphasis on wartime operations. Burns. 2014 Dec;40 Suppl 1:S24-9.

Abboud EC, Settle JC, Legare TB, Marcet JE, Barillo D3, Sanchez JE. Silver-based dressings for the reduction of surgical site infection: review of current experience and recommendation for future studies. Burns. 2014 Dec;40 Suppl 1:S30-9.

Krieger BR, Davis DM, Sanchez JE, Mateka JJ, Nfonsam VN, Frattini JC, Marcet JE. The use of silver nylon in preventing surgical site infections following colon and rectal surgery. Dis Colon Rectum. 2011 Aug;54(8):1014-9.

Silver Ions and Nanoparticles are Broad Spectrum Antibacterials

Spadaro JA, Berger TJ, Barranco SD, Chapin SE, Becker RO. Antibacterial Effects of Silver Electrodes with Weak Direct Current. Antimicrobial Agents and Chemotherapy 1974;6(5):637-642.

Berger TJ, Spadaro JA, Chapin SE, Becker RO. Electrically Generated Silver Ions: Quantitative Effects on Bacterial and Mammalian Cells. Antimicrobial Agents and Chemotherapy 1976;9(2):357-358.

Morones-Ramirez JR, Winkler JA, Spina CS, Collins JJ. Silver Enhances Antibiotic Activity Against Gram-negative Bacteria. Science translational medicine 2013;5(190):190ra81.

Liau SY, Read DC, Pugh WJ, Furr JR, Russell AD. Interaction of silver nitrate with readily identifiable groups: relationship to the antibacterial action of silver ions. Lett Appl Microbiol. 1997 Oct;25(4):279-83.

Becker RO. Silver ions in the treatment of local infections. Met Based Drugs. 1999;6(4-5):311-4.

Xiu ZM, Zhang QB, Puppala HL, Colvin VL, Alvarez PJ. Negligible particle-specific antibacterial activity of silver nanoparticles. Nano Lett. 2012 Aug 8;12(8):4271-5.

Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M. Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects. Appl Microbiol Biotechnol. 2014 Mar;98(5):1951-61.

Silver Ions and Nanoparticles are Broad Spectrum Antivirals

 

Chen N, Zheng Y, Yin J, Li X, Zheng C. Inhibitory effects of silver nanoparticles against adenovirus type 3 in vitro. J Virol Methods. 2013 Nov;193(2):470-7.

Lara HH, Ayala-Nuñez NV, Ixtepan-Turrent L, Rodriguez-Padilla C. Mode of antiviral action of silver nanoparticles against HIV-1. Journal of Nanobiotechnology 2010;8:1.

Gaikwad S, Ingle A, Gade A, et al. Antiviral activity of mycosynthesized silver nanoparticles against herpes simplex virus and human parainfluenza virus type 3. International Journal of Nanomedicine 2013;8:4303-4314.

Elechiguerra JL, Burt JL, Morones JR, Camacho-Bragado A, Gao X, Lara HH, Yacaman MJ. Interaction of silver nanoparticles with HIV-1. J Nanobiotechnology. 2005 Jun 29;3:6.

 

 

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